| Product name: |
Cdc25A (phospho Ser75) rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
CDC25A; M-phase inducer phosphatase 1; Dual specificity phosphatase Cdc25A |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen: |
Synthesized phospho-peptide around the phosphorylation site of human Cdc25A (phospho Ser75) |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
59kD |
| GeneID: |
993 |
| Human Swiss-Prot No: |
P30304 |
| Cellular localization: |
intracellular,nucleus,nucleoplasm,cytoplasm,cytosol, |
| Background: |
cell division cycle 25A(CDC25A) Homo sapiens CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
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